Should rheumatologists use Cox II selective NSAIDs, non-selective NSAIDs, or none at all?

Ocular Inflammation and Nsaids: an Overview with Selective and Non-selective Cox Inhibitors

Inflammation is a complex biological response and like other parts of the body, ocular inflammation could have untoward effects on vision if not detected and/or diagnosed early. NSAIDs are the major ocular therapeutics for treating such eye inflammations and preferred over corticosteroids. NSAIDs are given orally as well as topically to treat ocular inflammations, however topical route is prefe...

The double-edged sword of COX-2 selective NSAIDs.

The launch of the cyclooxygenase-2 (COX-2) selective NSAIDs was based on 2 hypotheses: (1) the major adverse effects limiting the usefulness of nonselective NSAIDs are gastrointestinal in nature and (2) COX-2 selective NSAIDs are associated with fewer gastrointestinal adverse effects than nonselective NSAIDs. At the time of the launch, neither of these hypotheses had been proven and, as documen...

Cyclooxygenase (COX-2) selective inhibitors. Any better than NSAIDs?

Review: misoprostol or COX-2-specific or selective NSAIDs reduce gastrointestinal complications and symptomatic ulcers.

M e t h o d s Data sources: 5 databases, bibliographies of relevant studies, and contacting authors. Study selection and assessment: Randomized controlled trials (RCTs) ≥ 21 days in duration comparing 1 of the 5 gastroprotective strategies with nonselective NSAIDs alone on outcomes of GI toxicity. Quality assessment included randomization procedures, allocation concealment, blinding, and follow...

When should COX-2 selective NSAIDs be used for osteoarthritis and rheumatoid arthritis?

Cyclo-oxygenase-2 (COX-2) selective nonsteroidal anti-inflammatory drugs (NSAIDs) are as effective as acetaminophen and nonselective NSAIDs in treating of osteoarthritis, and are equally effective in reducing pain and inflammation and improving of joint function for patients with rheumatoid arthritis, when compared with nonselective NSAIDs. The COX-2 selective NSAIDs also have a better gastroin...